Service Description

Evaluate compound in PPD's oncology model. After PPD's evaluation, initiate a co-development for the program. The objective for the company was clearly de-risk the program and take advantage of PPD's expertise up to the clinic

What Went Well

PPD was very proactive in establishing the required CDA and during the evaluation of the compounds. Experimental set-up was rapidly discussed in depth and their people demonstrated skills and expertise throughout the evalulation. Also, they showed a very clear view of their own objectives

What Could Be Improved

We had no particular issues with evaluations. We got enough specific informations in the report to understand what compounds demonstrated issues, including solubilitiy. Maybe one thing is the choice of the reference molecule to be compared with, which should be chosen according to the intended indication. I certainly encourage people to build the experimental plan with the CRO at their own need and not according to the CRO' practice

Lessons Learned from the Experience

I appreciated the dynamism, adaptability and the fact that there is a common objective beyond the study which is co-development. It is very important to negociate upfront how the results will be delivered and under which form and negociate the experimental plan according to the client's need.